If you have ever dined in Rome’s famous Roman Ghetto, you have most likely tried Spaghetti Cacio e Pepe. Situated in the Sant’Angelo district, the Roman Ghetto is rich in history and boasts some of the best rustic “comfort-food” cuisine in all of Italy. Cacio e Pepe – meaning literally cheese and pepper – is so simple, but packs a major punch. The sharpness of fresh, salty pecorino romano cheese and freshly grated course black pepper tossed with perfectly al dente spaghetti is pure heaven.